Kim Okjin, Kim Kyung-Suk
Department of Laboratory Animal Sciences, College of Medicine, Seoul National University, South Korea.
J Vet Med Sci. 2005 Jan;67(1):121-3. doi: 10.1292/jvms.67.121.
A male 8-year-old Yorkshire Terrier dog with unilateral cryptorchism was presented for investigation of reduced appetite and multifocal alopecia. Abdominal sonography and radiography demonstrated abnormal enlargement of left testicle in abdominal cavity. Both of the retroperitoneal cryptorchid testicle and the other contralateral testicle were removed surgically. The concentrations of testosterone and estradiol in blood collected from the jugular vein and the two spermatic veins were evaluated and the results revealed high estradiol concentration. The retroperitoneal cryptorchid testicle was enlarged, firm, bulging sphere mass. The cut surface revealed homogeneous white color and lobulation by septa. The contralateral testicle in scrotum showed atrophic testicle and enlarged epididymis. Histopathologically, the retroperitoneal cryptorchid testicle was diagnosed as seminoma. We thought that hyperesterogenemia and alopecia in this case was probably related with his seminoma, although high correlations between Sertoli cell tumor and alopecia have been reported. To our knowledge, this report may be a rare case of seminoma with hyperesterogenemia and alopecia.
一只8岁雄性约克夏梗犬，患有单侧隐睾症，因食欲减退和多灶性脱毛前来就诊。腹部超声和X线检查显示腹腔内左侧睾丸异常增大。手术切除了腹膜后隐睾和对侧睾丸。对从颈静脉和两条精索静脉采集的血液中的睾酮和雌二醇浓度进行了评估，结果显示雌二醇浓度较高。腹膜后隐睾增大、质地坚硬，呈球形突出肿块。切面呈均匀白色，有隔膜分隔呈分叶状。阴囊内的对侧睾丸显示萎缩，附睾肿大。组织病理学检查显示，腹膜后隐睾被诊断为精原细胞瘤。我们认为，尽管有报道称支持细胞瘤与脱毛之间存在高度相关性，但该病例中的高雌激素血症和脱毛可能与精原细胞瘤有关。据我们所知，本报告可能是一例罕见的伴有高雌激素血症和脱毛的精原细胞瘤病例。
