Lloyd Jacqueline J, Chen Chuan-Yu, Storr Carla L, Anthony James C
School of Social Work, University of Maryland, Baltimore, Maryland 21201, USA.
J Stud Alcohol. 2004 Nov;65(6):750-7. doi: 10.15288/jsa.2004.65.750.
In this study, we sought to identify specific clinical features of alcohol dependence and other characteristics of recent drinkers that might help differentiate drinkers who receive treatment.
In 1998, field staff for the National Household Survey on Drug Abuse assessed 18,722 sampled adults, including 12,437 who reported drinking in the year prior to survey, most of whom self-marked answers to standard items on drug experiences, including clinical features of alcohol dependence and receipt of treatment. Statistical analyses took into account the complex sampling procedures and the interdependencies between individual responses.
Multivariate modeling with generalized linear model and generalized estimating equations with statistical adjustment for age, gender and race revealed that individuals who received treatment reported all seven clinical features more often than drinkers who did not receive treatment, with the greatest differences observed for alcohol-related emotional problems (adjusted odds ratio [adj. OR] = 15.0), health problems (adj. OR = 13.5), reduced important activities (adj. OR = 10.4) and inability to cut down (adj. OR = 10.1) (all p values < .05). The observed treatment-related differences were less pronounced for other clinical features (e.g., reported tolerance [adj. OR = 4.8], using more than was intended [adj. OR = 6.2] and salience of alcohol-related behavior [adj. OR = 6.2]; all p values < .05). Further statistical adjustment for frequency of alcohol use and age of first alcohol use did not alter these estimates appreciably.
Reasons for observed excess occurrence of alcohol-related problems among community samples of drinkers who receive treatment deserve more attention in future research. A key research question is whether self-awareness of alcohol-related problems motivates drinkers to seek treatment or if treatment promotes awareness and decreases denial about alcohol problems.
在本研究中,我们试图确定酒精依赖的特定临床特征以及近期饮酒者的其他特征,这些特征可能有助于区分接受治疗的饮酒者。
1998年,全国药物滥用家庭调查的现场工作人员对18722名抽样成年人进行了评估,其中包括12437名在调查前一年报告饮酒的人,他们中的大多数人自行填写了关于药物使用经历的标准项目答案,包括酒精依赖的临床特征和接受治疗情况。统计分析考虑了复杂的抽样程序以及个体回答之间的相互依存关系。
使用广义线性模型和广义估计方程进行多变量建模,并对年龄、性别和种族进行统计调整,结果显示,接受治疗的个体比未接受治疗的饮酒者更频繁地报告所有七种临床特征,其中与酒精相关的情绪问题(调整后的优势比[adj. OR]=15.0)、健康问题(adj. OR = 13.5)、重要活动减少(adj. OR = 10.4)和无法减少饮酒量(adj. OR = 10.1)的差异最为显著(所有p值<0.05)。对于其他临床特征,观察到的与治疗相关的差异不太明显(例如,报告的耐受性[adj. OR = 4.8]、饮酒量超过预期[adj. OR = 6.2]以及酒精相关行为的显著性[adj. OR = 6.2];所有p值<0.05)。进一步对饮酒频率和首次饮酒年龄进行统计调整,并没有明显改变这些估计值。
在未来的研究中,接受治疗的饮酒者社区样本中酒精相关问题发生率过高的原因值得更多关注。一个关键的研究问题是,对酒精相关问题的自我认知是否促使饮酒者寻求治疗,或者治疗是否能提高认知并减少对酒精问题的否认。