水分散性荧光、不透射线且具有顺磁性的硫化镉：锰/硫化锌量子点的合成：一种用于生物成像的多功能探针
Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: a multifunctional probe for bioimaging.
作者信息
Santra Swadeshmukul, Yang Heesun, Holloway Paul H, Stanley Jessie T, Mericle Robert A
机构信息
Department of Neurological Surgery, University of Florida, P.O. Box 100265, Gainesville, FL 32610, USA.
出版信息
J Am Chem Soc. 2005 Feb 16;127(6):1656-7. doi: 10.1021/ja0464140.
Ultra-small (3.1 nm) multifunctional CdS:Mn/ZnS core-shell semiconductor quantum dots (Qdots), which possess fluorescent, radio-opacity, and paramagnetic properties, have been shown here. To demonstrate in vivo bioimaging capability, a rat was administered endovascularly with Qdots conjugated with a TAT peptide. The labeling efficacy of these Qdots was demonstrated on the basis of the histological analysis of the microtome sliced brain tissue, clearly showing that TAT-conjugated Qdots stained brain blood vessels.
本文展示了超小（3.1纳米）的多功能硫化镉：锰/硫化锌核壳半导体量子点（Qdots），其具有荧光、射线不透性和顺磁性特性。为了证明体内生物成像能力，对一只大鼠进行血管内注射与TAT肽偶联的量子点。基于对切片脑组织的组织学分析证明了这些量子点的标记效果，清楚地表明与TAT偶联的量子点对脑血血管进行了染色。
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