Dib Jean G
School of Pharmacy, Lebanese American University, Lebanon.
Curr Med Res Opin. 2004 Dec;20(12):1857-61. doi: 10.1185/030079904X11358.
Topiramate is a drug that has shown efficacy in the treatment of epilepsy. A survey of MEDLINE, EMBASE and the American Academy of Neurology Abstracts reveals there is now evidence that topiramate is also effective in the treatment of neuropathic pain. The dose that has been studied ranges from 25 mg to 800 mg with a suggested dose of 400 mg daily. However, further randomized, double blind studies are needed to confirm this new use of topiramate and explore the proper dose and mechanism of action. Topiramate is conspicuous amongst the antiepileptic drugs for being well tolerated and having fewer drug interactions. Thus, it might offer an advantage over such drugs.
托吡酯是一种已显示出对癫痫治疗有效的药物。对MEDLINE、EMBASE和美国神经病学学会摘要的一项调查显示，现在有证据表明托吡酯在治疗神经性疼痛方面也有效。所研究的剂量范围为25毫克至800毫克，建议每日剂量为400毫克。然而，需要进一步的随机双盲研究来证实托吡酯的这种新用途，并探索合适的剂量和作用机制。托吡酯在抗癫痫药物中很突出，因为它耐受性良好且药物相互作用较少。因此，它可能比这类药物具有优势。
