Fickweiler U, Fickweiler K
Klinik für Hals-, Nasen-, Ohrenheilkunde/Plastische Operationen des Universitätsklinikums Leipzig.
HNO. 2005 Aug;53(8):735-40. doi: 10.1007/s00106-004-1200-3.
Bacterial rhinosinusitis is one of the most frequent indications for an antibiotic therapy. The objective of this study was the analysis of the current pathogen spectrum and its antimicrobial susceptibility.
Between 1999 and 2004, 188 specimens obtained from 170 patients with acute, purulent rhinosinusitis were analysed.
A total of 217 pathogens were isolated. The most common isolates were Streptococcus pneumoniae (33%), Haemophilus influenzae (27%), Staphylococcus aureus (13%), Moraxella catarrhalis (11%) and streptococci (7%). S. pneumoniae, H. influenzae and M. catarrhalis were the predominant pathogens in children. S. pneumoniae, S. aureus and streptococci, however, dominated in specimens from adults.
Based on these results, adults should be treated with an aminopenicillin with beta-lactamase inhibitor or a cephalosporin of the second generation. For children , however, the first line antibiotic is an aminopenicillin.
细菌性鼻窦炎是抗生素治疗最常见的适应症之一。本研究的目的是分析当前的病原体谱及其抗菌药敏性。
1999年至2004年期间,对170例急性化脓性鼻窦炎患者的188份标本进行了分析。
共分离出217种病原体。最常见的分离菌为肺炎链球菌(33%)、流感嗜血杆菌(27%)、金黄色葡萄球菌(13%)、卡他莫拉菌(11%)和链球菌(7%)。肺炎链球菌、流感嗜血杆菌和卡他莫拉菌是儿童的主要病原体。然而,肺炎链球菌、金黄色葡萄球菌和链球菌在成人标本中占主导地位。
基于这些结果,成人应使用含β-内酰胺酶抑制剂的氨基青霉素或第二代头孢菌素进行治疗。然而,对于儿童,一线抗生素是氨基青霉素。