激素避孕药会刺激神经纤维瘤生长吗？一项对59例1型神经纤维瘤病患者的调查。
Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients.
作者信息
Lammert Marge, Mautner Victor-Felix, Kluwe Lan
机构信息
Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany.
出版信息
BMC Cancer. 2005 Feb 9;5:16. doi: 10.1186/1471-2407-5-16.
BACKGROUND
Neurofibromas are benign tumors of the peripheral nerves and hallmark of neurofibromatosis type 1 (NF1), a tumor suppressor gene syndrome. Neurofibromas mostly start developing at puberty and can increase in size and number during pregnancy. Expression of progesterone receptors has been found in 75% of the tumors. Many female NF1 patients are thus concerned about the possibility that hormonal contraceptives may stimulate the growth of their neurofibromas.
METHODS
A survey was carried out on 59 female NF1 patients who are practicing or have practiced hormonal contraception to examine the effect of the various contraceptives on the growth of neurofibromas.
RESULTS
Majority (53 out of 58) of patients who received oral estrogen-progestogen or pure progestogen preparations reported no associated tumor growth. In contrast, significant tumor growth was reported by two patients who received depot contraceptive containing high dose of synthetic progesterone.
CONCLUSIONS
Oral contraceptives do not seem to stimulate the growth of neurofibromas in NF1 patients. High doses of progesterone might stimulate the growth of neurofibromas and deserve more caution.
背景
神经纤维瘤是周围神经的良性肿瘤，也是1型神经纤维瘤病（NF1）的标志，NF1是一种肿瘤抑制基因综合征。神经纤维瘤大多在青春期开始生长，在怀孕期间其大小和数量可能会增加。已发现75%的肿瘤中存在孕激素受体表达。因此，许多患有NF1的女性患者担心激素避孕药可能会刺激她们神经纤维瘤的生长。
方法
对59名正在使用或曾经使用过激素避孕的NF1女性患者进行了一项调查，以研究各种避孕药对神经纤维瘤生长的影响。
结果
大多数（58名患者中的53名）接受口服雌激素 - 孕激素或单纯孕激素制剂的患者报告神经纤维瘤无相关生长。相比之下，两名接受高剂量合成孕激素长效避孕针的患者报告神经纤维瘤有显著生长。
结论
口服避孕药似乎不会刺激NF1患者神经纤维瘤的生长。高剂量孕激素可能会刺激神经纤维瘤的生长，值得更加谨慎对待。
Zotero 插件