Grebien Florian, Dolznig Helmut, Beug Hartmut, Mullner Ernst W
Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria.
Cell Cycle. 2005 Mar;4(3):418-21. doi: 10.4161/cc.4.3.1523. Epub 2005 Mar 4.
Continuously proliferating cells have to precisely double their size during each cycle to maintain constant volumes. Time and again, this fact raised questions on the existence of an active cell size control mechanism in eukaryotic cells, which would prevent delayed or premature cell division at inadequate mass. We addressed this open issue by recapitulating in animal cells several long-standing experiments which had identified such a mechanism in yeast.
持续增殖的细胞在每个周期中必须精确地使自身大小翻倍,以维持恒定的体积。这一事实反复引发了关于真核细胞中是否存在主动细胞大小控制机制的问题,该机制可防止在质量不足时出现细胞分裂延迟或过早分裂的情况。我们通过在动物细胞中重现几个长期存在的实验来解决这个悬而未决的问题,这些实验在酵母中鉴定出了这样一种机制。