烯烃交叉复分解反应中的自选择：远程官能团的影响。

Self-selection in olefin cross-metathesis: the effect of remote functionality.

作者信息

McNaughton Brian R, Bucholtz Kevin M, Camaaño-Moure Ana, Miller Benjamin L

机构信息

Department of Dermatology, Department of Chemistry, and The Center for Future Health, University of Rochester, Rochester, NY 14642, USA.

出版信息

Org Lett. 2005 Feb 17;7(4):733-6. doi: 10.1021/ol047361u.

DOI:10.1021/ol047361u

PMID:15704937

Abstract

Olefin cross-metathesis (CM) is potentially an attractive method for generating dynamic combinatorial libraries (DCLs). In order for the CM reaction to be useful for DCL production, the course of the reaction and product distribution must be relatively insensitive to functionality remote from the reacting centers. We report on the CM of a series of allyl- and homoallylamides that are strongly dependent on remote functionality. This includes an unusual example of a cis-selective CM. [Reaction: see text]

摘要

烯烃交叉复分解反应（CM）在生成动态组合库（DCL）方面可能是一种颇具吸引力的方法。为了使CM反应适用于DCL的制备，反应过程和产物分布必须对远离反应中心的官能团相对不敏感。我们报道了一系列烯丙基酰胺和高烯丙基酰胺的CM反应，这些反应强烈依赖于远程官能团。这包括一个顺式选择性CM的不寻常例子。[反应：见正文]