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Synthesis, crystal structure and molecular conformation of Nalpha-Boc-L-leucyl-(Z)-beta-(3-pyridyl)-alpha,beta- dehydroalanyl-L-leucine methyl ester.

作者信息

Yamada K, Oku H, Shinoda S-S, Katakai R

机构信息

Department of Chemistry, Gunma University, Tenjin-cho, Kiryu, Gunma, Japan.

出版信息

J Pept Res. 2005 Feb;65(2):167-74. doi: 10.1111/j.1399-3011.2005.00232.x.

DOI:10.1111/j.1399-3011.2005.00232.x
PMID:15705161
Abstract

A protected tridehydropeptide containing (Z)-beta-(3-pyridyl)-alpha,beta-dehydroalanine (Delta(Z)3Pal) residue, Boc-Leu-Delta(Z)3Pal-Leu-OMe (1), was synthesized via Erlenmeyer azlactone method. X-ray crystallographic analysis revealed that the peptide 1 adopts an extended conformation, which is similar to that of a Delta(Z)Phe analog, Boc-Leu-Delta(Z)Phe-Leu-OMe (2).

摘要

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