转基因小鼠乳腺上皮细胞中雌激素受体α表达失调会导致原位导管癌的发生。
Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ.
作者信息
Frech M Silvina, Halama Ewa D, Tilli Maddalena T, Singh Baljit, Gunther Edward J, Chodosh Lewis A, Flaws Jodi A, Furth Priscilla A
机构信息
Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA.
出版信息
Cancer Res. 2005 Feb 1;65(3):681-5.
Abstract
A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor alpha expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age. Higher proliferative rates were found in both normal and abnormal ductal and lobular structures. DH and DCIS but not normal ductal structures showed an increased percentage of cells with nuclear-localized cyclin D1. No differences in either the prevalence or extent of these phenotypes following exogenous 17beta-estradiol treatment were found suggesting that alteration of ERalpha expression was the rate-limiting factor in initiation of DH, lobular hyperplasia, and DCIS.
摘要
一种在乳腺上皮细胞中雌激素受体α表达失调的条件性四环素反应性转基因小鼠模型，在4月龄时出现了导管增生（DH）、小叶增生和原位导管癌（DCIS）。在正常和异常的导管及小叶结构中均发现了较高的增殖率。DH和DCIS而非正常导管结构显示核定位细胞周期蛋白D1的细胞百分比增加。在外源性17β-雌二醇处理后，这些表型的发生率或程度均未发现差异，这表明ERα表达的改变是DH、小叶增生和DCIS发生的限速因素。
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本文引用的文献
1
Introduction of estrogen receptor-alpha into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma.
Am J Pathol. 2003 Nov;163(5):1713-9. doi: 10.1016/s0002-9440(10)63529-8.
2
Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast.
Eur J Cancer. 2003 Mar;39(5):622-30. doi: 10.1016/s0959-8049(02)00666-4.
3
Biological and molecular characteristics of the premalignant mouse mammary gland.
Biochim Biophys Acta. 2002 Oct 2;1603(1):1-9. doi: 10.1016/s0304-419x(02)00053-7.
4
Conditional over-expression of estrogen receptor alpha in a transgenic mouse model.
Transgenic Res. 2002 Aug;11(4):361-72. doi: 10.1023/a:1016376100186.
5
Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu.
Cancer Res. 2002 May 15;62(10):2798-805.
6
A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology.
FASEB J. 2002 Mar;16(3):283-92. doi: 10.1096/fj.01-0551com.
7
Histological and biological evolution of human premalignant breast disease.
Endocr Relat Cancer. 2001 Mar;8(1):47-61. doi: 10.1677/erc.0.0080047.
8
Expression of p21Waf1, p27Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status.
Pathol Int. 2001 Feb;51(2):94-9. doi: 10.1046/j.1440-1827.2001.01173.x.
9
Mammary gland development and tumorigenesis in estrogen receptor knockout mice.
J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):323-34. doi: 10.1023/a:1026339111278.
10
Estrogen receptor-positive proliferating cells in the normal and precancerous breast.
Am J Pathol. 1999 Dec;155(6):1811-5. doi: 10.1016/S0002-9440(10)65498-3.
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