Nassir Ghaemi S, Miller Christopher J, Berv Douglas A, Klugman Jeffry, Rosenquist Klara J, Pies Ronald W
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA.
J Affect Disord. 2005 Feb;84(2-3):273-7. doi: 10.1016/S0165-0327(03)00196-4.
To assess the sensitivity and specificity of a self-report questionnaire for bipolar disorder, the Bipolar Spectrum Diagnostic Scale (BSDS).
The BSDS was administered to 68 consecutive patients with bipolar illness and 27 consecutive patients with unipolar major depressive disorder. Created by Ronald Pies, it consists of a descriptive story that captures subtle features of bipolar illness, to which patients may assent on a sentence-by-sentence basis. BSDS scores were compared to clinicians' DSM-IV-based diagnoses.
Sensitivity of the BSDS was 0.76, approximately equal in bipolar I and II/NOS subjects (0.75 and 0.79, respectively). The BSDS identified 85% of unipolar-depressed patients as not having bipolar spectrum illness. A shift in the threshold of the BSDS resulted in a large increase in specificity (from 0.85 to 0.93), without a significant loss of sensitivity.
The BSDS was highly sensitive and specific for bipolar spectrum illness, especially with the amended threshold for positive diagnosis.
评估用于双相情感障碍的自填式问卷——双相谱诊断量表（BSDS）的敏感性和特异性。
对68例连续的双相情感障碍患者和27例连续的单相重度抑郁症患者进行BSDS测试。该量表由罗纳德·皮斯编制，包含一个描述性故事，体现了双相情感障碍的细微特征，患者可逐句表示赞同。将BSDS得分与基于《精神疾病诊断与统计手册》第四版（DSM-IV）的临床医生诊断结果进行比较。
BSDS的敏感性为0.76，在双相I型和II型/未特定型（NOS）患者中大致相同（分别为0.75和0.79）。BSDS将85%的单相抑郁患者判定为不患有双相谱疾病。BSDS阈值的改变使特异性大幅提高（从0.85提高到0.93），且敏感性无显著损失。
BSDS对双相谱疾病具有高度敏感性和特异性，尤其是在修正了阳性诊断阈值之后。
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