抗癌药物与DNA相互作用的电化学方法。

Electrochemical approach of anticancer drugs--DNA interaction.

作者信息

Rauf S, Gooding J J, Akhtar K, Ghauri M A, Rahman M, Anwar M A, Khalid A M

机构信息

Bioprocess Technology Division, National Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.

出版信息

J Pharm Biomed Anal. 2005 Feb 23;37(2):205-17. doi: 10.1016/j.jpba.2004.10.037.

DOI:10.1016/j.jpba.2004.10.037

PMID:15708659

Abstract

The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. In recent years there has been a growing interest in the electrochemical investigation of interaction between anticancer drugs and DNA. Observing the pre and post electrochemical signals of DNA or drug interaction provides good evidence for the interaction mechanism to be elucidated. Also this interaction could be used for the quantification of these drugs and for the determination of new drugs targeting DNA. Electrochemical approach can provide new insight into rational drug design and would lead to further understanding of the interaction mechanism between anticancer drugs and DNA.

摘要

药物与DNA的相互作用是药物发现和药物开发过程中生物学研究的最重要方面之一。近年来，人们对抗癌药物与DNA相互作用的电化学研究兴趣日益浓厚。观察DNA或药物相互作用前后的电化学信号为阐明相互作用机制提供了有力证据。此外，这种相互作用可用于这些药物的定量分析以及靶向DNA的新药的测定。电化学方法可为合理的药物设计提供新的见解，并有助于进一步了解抗癌药物与DNA之间的相互作用机制。