Salehian Omid, Horlick Eric, Schwerzmann Markus, Haberer Kim, McLaughlin Peter, Siu Samuel C, Webb Gary, Therrien Judith
Toronto Congenital Center for Adults and Echocardiography Laboratory, University of Toronto, Ontario, Canada.
J Am Coll Cardiol. 2005 Feb 15;45(4):499-504. doi: 10.1016/j.jacc.2004.10.052.
We set out to study the effect of transcatheter closure of atrial septal defect (ASD) on right ventricular (RV) and left ventricular (LV) function assessed by myocardial performance index (MPI), as well as left atrial (LA) volumes.
The hemodynamic response to the closure of ASD is well-documented in surgically treated patients. However, few studies have documented echocardiographic evaluation of ventricular function in patients undergoing transcatheter closure of ASDs.
Pre- and post-ASD device closure echocardiograms of 25 consecutive patients were retrospectively reviewed. Measurements of RV and LV MPI and LA volumes were made.
Twenty-five patients with an average age of 45.5 +/- 16.3 years underwent transcatheter closure of ASD. There was statistically significant improvement in RV MPI (0.35 to 0.28, p = 0.004), LV MPI (0.37 to 0.31, p = 0.04), and LA volume index (25.7 to 21.8 ml/m(2), p < 0.001) after closure of ASD.
Device closure of ASDs leads to improvement of both RV and LV function as well as reduction in LA volume. These hemodynamic improvements provide insights into the symptomatic benefits gained in closure of ASDs using the transcatheter approach.
我们旨在研究经导管封堵房间隔缺损（ASD）对通过心肌性能指数（MPI）评估的右心室（RV）和左心室（LV）功能以及左心房（LA）容积的影响。
在接受手术治疗的患者中，ASD封堵后的血流动力学反应已有充分记录。然而，很少有研究记录经导管封堵ASD患者的心室功能的超声心动图评估。
回顾性分析连续25例患者在ASD封堵装置置入前后的超声心动图。测量RV和LV的MPI以及LA容积。
25例平均年龄为45.5±16.3岁的患者接受了经导管ASD封堵术。ASD封堵后，RV的MPI（从0.35降至0.28，p = 0.004）、LV的MPI（从0.37降至0.31，p = 0.04）和LA容积指数（从25.7降至21.8 ml/m²，p < 0.001）有统计学意义的改善。
ASD封堵装置可改善RV和LV功能，并减少LA容积。这些血流动力学改善为经导管封堵ASD所带来的症状改善提供了见解。
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