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人多发性骨髓瘤细胞缺乏核因子-κB受体激活剂配体（RANKL）的表达及功能性产生。

Lack of receptor activator of nuclear factor-kB ligand (RANKL) expression and functional production by human multiple myeloma cells.

作者信息

Giuliani Nicola, Colla Simona, Morandi Francesca, Barille-Nion Sophie, Rizzoli Vittorio

出版信息

Haematologica. 2005 Feb;90(2):275-8.

PMID:15710592
Abstract

The direct expression and production of the critical osteoclastogenic factor, the receptor activator of NF-kB ligand (RANKL), is a matter of controversy. In this study we definitively demonstrate by both qualitative and quantitative polymerase chain reaction analysis that human myeloma cells do not express significant levels of RANKL mRNA or produce RANKL able to stimulate osteoclast formation.

摘要

关键破骨细胞生成因子——核因子κB受体活化因子配体（RANKL）的直接表达和产生存在争议。在本研究中，我们通过定性和定量聚合酶链反应分析明确证明，人骨髓瘤细胞不会表达显著水平的RANKL mRNA，也不会产生能够刺激破骨细胞形成的RANKL。

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