Cholesterol detoxification by the nuclear pregnane X receptor.
作者信息
Kliewer Steven A
机构信息
Departmens of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.
出版信息
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2675-6. doi: 10.1073/pnas.0500159102. Epub 2005 Feb 14.
Abstract
摘要
相似文献
1
Cholesterol detoxification by the nuclear pregnane X receptor.核孕烷X受体介导的胆固醇解毒作用
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2675-6. doi: 10.1073/pnas.0500159102. Epub 2005 Feb 14.
2
Regulation of hepatic drug metabolism: role of the nuclear receptors PXR and CAR.肝脏药物代谢的调控：核受体PXR和CAR的作用
Semin Liver Dis. 2002;22(2):115-22. doi: 10.1055/s-2002-30098.
3
[Nuclear receptor regulation of cholesterol metabolism].[核受体对胆固醇代谢的调控]
Nihon Rinsho. 2001 Feb;59 Suppl 2:468-71.
4
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.CAR和PXR激动剂可刺激小鼠肝脏中的胆汁酸和胆红素解毒及消除途径。
Hepatology. 2005 Aug;42(2):420-30. doi: 10.1002/hep.20784.
5
International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.国际药理学联合会。LXII. NR1H和NR1I受体：组成型雄烷受体、孕烷X受体、法尼醇X受体α、法尼醇X受体β、肝X受体α、肝X受体β和维生素D受体。
Pharmacol Rev. 2006 Dec;58(4):742-59. doi: 10.1124/pr.58.4.6.
6
The role of pregnane X receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.孕烷X受体在2-乙酰氨基芴介导的小鼠药物转运和代谢酶诱导中的作用。
Drug Metab Dispos. 2006 Mar;34(3):405-9. doi: 10.1124/dmd.105.006197. Epub 2005 Dec 28.
7
C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.秀丽隐杆线虫的DAF-12、核激素受体与人类老年期的长寿和疾病
Ageing Res Rev. 2005 Aug;4(3):351-71. doi: 10.1016/j.arr.2005.03.006.
8
The nuclear pregnane X receptor regulates xenobiotic detoxification.核孕烷X受体调节外源性物质的解毒作用。
J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S. doi: 10.1093/jn/133.7.2444S.
9
[Advances in the research of pregnane X receptor and constitutive androstane receptor].孕烷X受体与组成型雄烷受体的研究进展
Yao Xue Xue Bao. 2011 Oct;46(10):1173-7.
10
Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.古古甾酮激活多种核受体，并通过孕烷X受体诱导CYP3A基因表达。
J Pharmacol Exp Ther. 2004 Aug;310(2):528-35. doi: 10.1124/jpet.103.064329. Epub 2004 Apr 1.
引用本文的文献
1
Novel Approaches to Characterize Individual Drug Metabolism and Advance Precision Medicine.探索个体药物代谢特征的新方法，推进精准医学发展。
Drug Metab Dispos. 2023 Oct;51(10):1238-1253. doi: 10.1124/dmd.122.001066. Epub 2023 Jul 7.
2
Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.邻苯二甲酸二环己酯暴露对小鼠 PXR 激活和脂代谢平衡的影响。
Environ Health Perspect. 2021 Dec;129(12):127001. doi: 10.1289/EHP9262. Epub 2021 Dec 1.
3
Opioid Use and Rate of Nicotine Metabolism Among Pregnant Smokers.孕妇吸烟人群中阿片类药物使用与尼古丁代谢率。
Nicotine Tob Res. 2020 May 26;22(6):1046-1050. doi: 10.1093/ntr/ntz073.
4
Phosphorylation and subcellular localization of Na/H exchanger isoform 3 (NHE) are associated with altered gallbladder absorptive function after formation of cholesterol gallstones.钠/氢交换体3（NHE）的磷酸化和亚细胞定位与胆固醇结石形成后胆囊吸收功能的改变有关。
J Physiol Biochem. 2017 Feb;73(1):133-139. doi: 10.1007/s13105-016-0533-1. Epub 2016 Nov 7.
5
Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.甘草次酸通过改变脂筏中 Gαs 的位置协同增强β₂-肾上腺素能受体-Gs 信号传导。
PLoS One. 2012;7(9):e44921. doi: 10.1371/journal.pone.0044921. Epub 2012 Sep 27.
6
Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.动脉粥样硬化消退、2 型糖尿病消除和痴呆预防中的基因激活机制。
Curr Mol Med. 2011 Jul;11(5):391-400. doi: 10.2174/156652411795976556.
7
Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.细胞色素P450与基因激活——从药理学到胆固醇清除及动脉粥样硬化消退
Eur J Clin Pharmacol. 2008 Sep;64(9):841-50. doi: 10.1007/s00228-008-0515-5. Epub 2008 Jul 17.
8
The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope.广谱抗病毒药物甘草甜素可直接调节质膜和HIV-1包膜的流动性。
Biochem J. 2005 Nov 15;392(Pt 1):191-9. doi: 10.1042/BJ20051069.
本文引用的文献
1
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.孕烷X受体可预防胆固醇代谢产物引起的肝肾毒性。
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2198-203. doi: 10.1073/pnas.0409481102. Epub 2005 Jan 25.
2
Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes.2,3-氧化角鲨烯：羊毛甾醇环化酶抑制剂对CYP3A的诱导作用由原代培养大鼠肝细胞中的一种内源性角鲨烯代谢产物介导。
Mol Pharmacol. 2004 May;65(5):1302-12. doi: 10.1124/mol.65.5.1302.
3
CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.肝脏X受体配体在原代培养的大鼠和小鼠肝细胞中对细胞色素P450 3A（CYP3A）的诱导作用是由孕烷X受体介导的。
Drug Metab Dispos. 2004 Jan;32(1):66-71. doi: 10.1124/dmd.32.1.66.
4
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.鉴定一种激活孕烷X受体介导的甾醇清除的内源性配体。
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):833-8. doi: 10.1073/pnas.0336235100.
5
Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).
J Nutr Biochem. 2002 Dec;13(12):700-710. doi: 10.1016/s0955-2863(02)00222-x.
6
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.鉴定胆汁酸前体作为核外源性孕烷X受体的内源性配体。
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8. doi: 10.1073/pnas.0237082100. Epub 2002 Dec 30.
7
The nuclear receptor PXR: a master regulator of "homeland" defense.核受体PXR：“本土”防御的主要调节因子。
Crit Rev Eukaryot Gene Expr. 2002;12(1):53-64. doi: 10.1615/critreveukaryotgeneexpr.v12.i1.30.
8
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.核孕烷X受体：外源性物质代谢的关键调节因子。
Endocr Rev. 2002 Oct;23(5):687-702. doi: 10.1210/er.2001-0038.
9
Metabolism of 4 beta -hydroxycholesterol in humans.人体内4β-羟基胆固醇的代谢
J Biol Chem. 2002 Aug 30;277(35):31534-40. doi: 10.1074/jbc.M201712200. Epub 2002 Jun 20.
10
Orphan nuclear receptors: the exotics of xenobiotics.孤儿核受体：外源性物质中的异类
J Biol Chem. 2001 Oct 12;276(41):37739-42. doi: 10.1074/jbc.R100033200. Epub 2001 Jul 17.
Zotero 插件