国际药理学联合会。LXII. NR1H和NR1I受体：组成型雄烷受体、孕烷X受体、法尼醇X受体α、法尼醇X受体β、肝X受体α、肝X受体β和维生素D受体。

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

作者信息

Moore David D, Kato Shigeaki, Xie Wen, Mangelsdorf David J, Schmidt Daniel R, Xiao Rui, Kliewer Steven A

机构信息

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Pharmacol Rev. 2006 Dec;58(4):742-59. doi: 10.1124/pr.58.4.6.

DOI:10.1124/pr.58.4.6

PMID:17132852

Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

摘要

NR1H和NR1I亚组的核受体包括组成型雄烷受体、孕烷X受体、法尼醇X受体、肝X受体和维生素D受体。这些相关受体的新出现功能受代谢途径的调控，包括外源性物质、胆汁酸、胆固醇和钙的代谢。本综述总结了这些受体的结构、药理学和遗传学研究结果。