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Alpha-Zearalanol, a phytoestrogen for cardiovascular therapy.

作者信息

Dai Shunling, Duan Jinhong, Lu Yuan, Cheng Jinxuan, Ren Jun, Deng Wenhui, Wu Yiyong

机构信息

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P. R. China 100005.

出版信息

Endocrine. 2004 Nov;25(2):117-9. doi: 10.1385/ENDO:25:2:117.

DOI:10.1385/ENDO:25:2:117
PMID:15711024
Abstract

Estrogen replacement therapy (ERT) is one of the most challenging issues women and their physicians have to face. Clinical and epidemiological studies have provided conflicting data regarding the cardiovascular benefit versus risk in women using ERT. Although ERT may improve several risk factors of coronary heart disease such as favorable changes in lipid profile, an associated increased incidence of uterine and breast tumors has jeopardized the clinical use of ERT. We reported here that the phytoestrogen alpha-zearalanol is effective against atherosclerotic development without overt growth-promoting effects in the uterus compared to estrogen. These results suggest clinical potential of this phytoestrogen as a "safe estrogen" with less risk of tumorogenesis.

摘要

相似文献

1
Alpha-Zearalanol, a phytoestrogen for cardiovascular therapy.
Endocrine. 2004 Nov;25(2):117-9. doi: 10.1385/ENDO:25:2:117.
2
Phytoestrogen alpha-zearalanol inhibits atherogenesis and improves lipid profile in ovariectomized cholesterol-fed rabbits.植物雌激素α-玉米赤霉醇抑制去卵巢高胆固醇喂养兔的动脉粥样硬化形成并改善血脂状况。
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Eur J Pharmacol. 2011 Nov 30;670(2-3):392-8. doi: 10.1016/j.ejphar.2011.09.016. Epub 2011 Sep 21.
4
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Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells.植物雌激素α-玉米赤霉醇拮抗同型半胱氨酸诱导的人脐静脉内皮细胞一氧化氮/内皮素-1失衡及细胞凋亡。
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Phytoestrogen alpha-zearalanol antagonizes oxidized LDL-induced inhibition of nitric oxide production and stimulation of endothelin-1 release in human umbilical vein endothelial cells.植物雌激素α-玉米赤霉醇可拮抗氧化型低密度脂蛋白诱导的人脐静脉内皮细胞一氧化氮生成抑制及内皮素-1释放刺激作用。
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[Effects of phytoestrogen alpha-zearalanol on normal human breast].
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The preventive and therapeutic roles of phytoestrogen α-Zearalanol on osteoporetic rats due to ovariectomization.植物雌激素α-玉米赤霉醇对去卵巢骨质疏松大鼠的防治作用
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本文引用的文献

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You've come a long way, baby: cardiovascular health and disease in women: problems and prospects.宝贝，你已经取得了很大的进步：女性心血管健康与疾病：问题与前景。
Circulation. 2004 Feb 10;109(5):558-60. doi: 10.1161/01.CIR.0000117292.19349.D0.
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Alleviation of plasma homocysteine level by phytoestrogen α-zearalanol might be related to the reduction of cystathionine β-synthase nitration.植物雌激素 α-玉米赤霉醇可能通过降低胱硫醚 β-合酶硝化来减轻血浆同型半胱氨酸水平。
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Phytoestrogen α-Zearalanol attenuates homocysteine-induced apoptosis in human umbilical vein endothelial cells.植物雌激素α-玉米赤霉醇可减轻同型半胱氨酸诱导的人脐静脉内皮细胞凋亡。
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Treatment with phytoestrogen alpha-zearalanol might protect neurons of hippocampus in ovariectomized rats.用植物雌激素α-玉米赤霉醇进行治疗可能会保护去卵巢大鼠海马体中的神经元。
Endocrine. 2006 Dec;30(3):249-54. doi: 10.1007/s12020-006-0001-8.
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Zearalenone--undesirable substances in feed.玉米赤霉烯酮——饲料中的不良物质。
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Circulation. 2001 Jul 24;104(4):499-503. doi: 10.1161/hc2901.092200.
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The phytoestrogen alpha-zearalenol reverses endothelial dysfunction induced by oophorectomy in rats.植物雌激素α-玉米赤霉醇可逆转大鼠卵巢切除所致的内皮功能障碍。
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