Biersack H-J, Ezziddin S, Risse J, Bender H, Palmedo H
Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Bonn.
Schmerz. 2005 Feb;19(1):9-17. doi: 10.1007/s00482-003-0293-z.
For more than 50 years now, nuclear medicine has offered therapeutic procedures in oncology. These comprise bone pain palliation in bone metastases of prostate and breast cancer. For more than 20 years now, metaiodobenzylguanidine (mIBG) has been used to treat neuroendocrine tumors. Ten years ago, somatostatin analogues such as Y-90 Dotatoc became available for the treatment of somatostatin receptor-positive tumors. The intracavitary injection of radiocolloids has been well known for 5 decades now and can be used in malignant effusions. Invasive procedures such as intra-arterial injection of I-131 lipiodol may be applied in multifocal, nonresectable hepatocellular carcinoma. Beyond that, intratumoral injection of radioisotopes may be used in cutaneous metastases. Radioimmunotherapy using labeled tumor antibodies is now also available, especially in patients with non-Hodgkin's lymphoma.
五十多年来，核医学一直在肿瘤学领域提供治疗方法。这些方法包括缓解前列腺癌和乳腺癌骨转移引起的骨痛。二十多年来，间碘苄胍（mIBG）一直用于治疗神经内分泌肿瘤。十年前，诸如钇-90 奥曲肽之类的生长抑素类似物开始用于治疗生长抑素受体阳性肿瘤。放射性胶体腔内注射已有五十年历史，可用于恶性积液。诸如动脉内注射碘-131 碘油之类的侵入性操作可应用于多灶性、不可切除的肝细胞癌。除此之外，瘤内注射放射性同位素可用于皮肤转移瘤。使用标记肿瘤抗体的放射免疫疗法目前也已应用，尤其是在非霍奇金淋巴瘤患者中。
