Hartmann Henrik A
Department of Pathology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA.
Neurotoxicology. 2005 Mar;26(2):277-83. doi: 10.1016/j.neuro.2003.09.015.
Iminodipropionitrile (IDPN) was given to rats on diets with normal copper levels, 5 ppm, and to rats on diets with high copper levels, 100 ppm. The former developed neurological symptoms, namely choreoathetoid head movements, circling and retropulsion, while the latter only showed vague incoordination. Since rats, raised on a copper deficient diet alone, i.e. 0.9 ppm develop the same symptoms, we assume that IDPN chelates copper. The axons of the motor nerve cells show metachromatic degeneration in the rats given IDPN on a diet with normal copper level, but not in the rats on a high copper level.
将亚氨基二丙腈（IDPN）分别给予正常铜水平（5 ppm）饮食的大鼠和高铜水平（100 ppm）饮食的大鼠。前者出现了神经症状，即舞蹈手足徐动样头部运动、转圈和后冲，而后者仅表现出轻微的不协调。由于仅以缺铜饮食（即0.9 ppm）饲养的大鼠也会出现相同症状，我们推测IDPN会螯合铜。在正常铜水平饮食的大鼠中，给予IDPN后运动神经细胞的轴突出现异染性变性，但在高铜水平饮食的大鼠中未出现。
