新型制霉素：非天然和天然氨基酸的掺入
Novel jadomycins: incorporation of non-natural and natural amino acids.
作者信息
Jakeman David L, Farrell Spring, Young Wendy, Doucet René J, Timmons Shannon C
机构信息
College of Pharmacy, Dalhousie University, 5968 College street, Halifax, Nova Scotia, B3H 3J5, Canada.
出版信息
Bioorg Med Chem Lett. 2005 Mar 1;15(5):1447-9. doi: 10.1016/j.bmcl.2004.12.082.
PMID:15713404
Abstract
Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural L-amino acids, D-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.
摘要
对委内瑞拉链霉菌ISP5230在化学合成的非天然L-氨基酸、D-氨基酸或20种天然氨基酸中的任何一种上生长的培养物提取物进行电喷雾电离质谱分析，结果表明氨基酸被掺入了一种杰多霉素B类似物中。
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