（E）-苯基和杂芳基取代的O-苯甲酰基（或酰基）肟类作为脂蛋白相关磷脂酶A2抑制剂。
(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors.
作者信息
Jeong Tae-Sook, Kim Mi Jeong, Yu Hana, Kim Kyung Soon, Choi Joong-Kwon, Kim Sung-Soo, Lee Woo Song
机构信息
National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2005 Mar 1;15(5):1525-7. doi: 10.1016/j.bmcl.2004.11.063.
A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.
合成了一系列 (E)-苯基和杂芳基取代的 O-苯甲酰基（或酰基）肟 3a-n，以评估它们对人脂蛋白相关磷脂酶 A2（Lp-PLA2）的抑制活性。亲脂性较低的衍生物 3a-c 对人 Lp-PLA2 表现出最强的体外抑制活性。
Zotero 插件