Iovanna Juan L, Dagorn Jean-Charles
INSERM U.624, Stress Cellulaire, 163 Avenue de Luminy, Case 915, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 9, France.
Biochim Biophys Acta. 2005 May 25;1723(1-3):8-18. doi: 10.1016/j.bbagen.2005.01.002. Epub 2005 Jan 21.
PSP/Lithostathine/PTP/regI, PAP/p23/HIP, reg1L, regIV and "similar to PAP" are the members of a multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide. The expression of this group of proteins is controlled by complex mechanisms, some members being constitutively expressed in certain tissues while, in others, they require activation by several factors. These members have several apparently unrelated biological effects, depending on the member studied and the target cell. These proteins may act as mitogenic, antiapoptotic or anti-inflammatory factors, can regulate cellular adhesion, promote bacterial aggregation, inhibit CaCO3 crystal growth or increase resistance to antitumoral agents. The presence of specific receptors for these proteins is suggested because biological effects were observed after the addition of purified protein to culture media or after systemic administration to animals, whereas other biological effects could be explained by their biochemical capacity to form homo or heteromers or to form insoluble fibrils at physiological pH.
PSP/锂抑素/PTP/regI、PAP/p23/HIP、reg1L、regIV以及“类PAP”是一个多功能分泌蛋白家族的成员，该家族包含一个与短N端肽相连的C型凝集素样结构域。这组蛋白的表达受复杂机制调控，一些成员在某些组织中组成性表达，而在其他组织中，它们需要多种因子激活。这些成员具有一些明显不相关的生物学效应，这取决于所研究的成员和靶细胞。这些蛋白可能作为促有丝分裂、抗凋亡或抗炎因子，可调节细胞黏附、促进细菌聚集、抑制碳酸钙晶体生长或增加对抗肿瘤药物的抗性。由于在向培养基中添加纯化蛋白后或对动物进行全身给药后观察到了生物学效应，因此提示存在这些蛋白的特异性受体，而其他生物学效应可以用它们在生理pH下形成同聚体或异聚体或形成不溶性原纤维的生化能力来解释。
