一种与Cbl相关蛋白结合蛋白激酶A的新型异构体。
A novel isoform of Cbl-associated protein that binds protein kinase A.
作者信息
Matson Sarah A, Pare Genevieve C, Kapiloff Michael S
机构信息
Department of Pediatrics, Oregon Health and Science University, NRC5, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, United States.
出版信息
Biochim Biophys Acta. 2005 Feb 14;1727(2):145-9. doi: 10.1016/j.bbaexp.2004.12.004. Epub 2004 Dec 28.
PMID:15716063
Abstract
A novel isoform of Cbl-associated protein (CAP) was identified in a yeast two-hybrid screen for A-kinase anchoring proteins expressed in the heart. CAP is a scaffold protein implicated in insulin signaling and cytoskeleton regulation. The protein kinase A binding site is encoded by a previously unidentified, alternatively spliced exon.
摘要
在一项针对心脏中表达的A激酶锚定蛋白的酵母双杂交筛选中，鉴定出了一种新型的Cbl相关蛋白（CAP）同工型。CAP是一种参与胰岛素信号传导和细胞骨架调节的支架蛋白。蛋白激酶A结合位点由一个先前未鉴定的可变剪接外显子编码。
Zotero 插件