Bak T H, Rogers T T, Crawford L M, Hearn V C, Mathuranath P S, Hodges J R
MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK.
J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):420-2. doi: 10.1136/jnnp.2003.029595.
Despite the growing recognition of the importance of cognitive symptoms for the diagnosis and management of atypical parkinsonian syndromes, the cognitive assessment of the patients in clinical practice often remains very limited.
To examine the ability of a brief and simple cognitive screening test to detect cognitive deficits in atypical parkinsonian syndromes.
Addenbrooke's cognitive examination (ACE), the mini-mental state examination (MMSE), and the dementia rating scale (DRS) were applied to 26 patients with multiple system atrophy (MSA), 39 with progressive supranuclear palsy (PSP), and 25 with corticobasal degeneration (CBD). The results were then compared with those obtained in 30 healthy age matched volunteers and 30 patients with Alzheimer's disease.
In all four diseases the rate of detection of cognitive impairment on ACE was higher than on MMSE and comparable with DRS. The severity of cognitive impairment was most pronounced in the CBD group, which showed a similar degree of impairment to the Alzheimer group. In contrast, MSA patients were the least cognitively impaired. The PSP group took an intermediate position.
Cognitive impairment in atypical parkinsonian syndromes can be detected using a brief and clinically applicable bedside test such as ACE.
尽管人们越来越认识到认知症状在非典型帕金森综合征的诊断和管理中的重要性，但临床实践中对患者的认知评估往往仍然非常有限。
研究一种简短且简单的认知筛查测试检测非典型帕金森综合征认知缺陷的能力。
对26例多系统萎缩（MSA）患者、39例进行性核上性麻痹（PSP）患者和25例皮质基底节变性（CBD）患者应用Addenbrooke认知检查（ACE）、简易精神状态检查表（MMSE）和痴呆评定量表（DRS）。然后将结果与30名年龄匹配的健康志愿者和30例阿尔茨海默病患者的结果进行比较。
在所有四种疾病中，ACE检测认知障碍的比率高于MMSE，与DRS相当。认知障碍的严重程度在CBD组最为明显，其受损程度与阿尔茨海默病组相似。相比之下，MSA患者的认知受损最少。PSP组处于中间位置。
使用ACE等简短且适用于临床床边测试可检测非典型帕金森综合征的认知障碍。
