Dickerson Roland N
University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):189-96. doi: 10.1097/00075197-200503000-00014.
Given the increased awareness of the detrimental complications of overfeeding, particularly hyperglycemia, the safety and efficacy of specialized nutritional support for the critically ill obese patient is of major concern. The intent of this review is to provide the scientific foundation, supporting and conflicting literature, for the implementation of hypocaloric, high-protein specialized nutritional support for acutely ill, hospitalized patients with obesity.
Similar anabolic equivalencies can be achieved with hypocaloric, high-protein nutritional support compared with a more traditional higher calorie, lower protein regimen. The provision of additional calories worsens hyperglycemia, results in a further accumulation of fat mass, and increases the potential for overfeeding without significant net protein anabolism gain.
The current literature indicates that hypocaloric, high-protein enteral or parenteral nutrition is promising as the standard of practice for the metabolic support of the critically ill obese patient. The achievement of net protein anabolism and the avoidance of overfeeding complications are the primary goals, with fat weight loss a welcome secondary benefit.
鉴于人们越来越意识到过度喂养的有害并发症,尤其是高血糖,为重症肥胖患者提供特殊营养支持的安全性和有效性备受关注。本综述旨在为对急性病住院肥胖患者实施低热量、高蛋白特殊营养支持提供科学依据、支持性及矛盾性文献。
与更传统的高热量、低蛋白方案相比,低热量、高蛋白营养支持可实现相似的合成代谢等效性。提供额外热量会使高血糖恶化,导致脂肪量进一步积累,并增加过度喂养的可能性,而不会显著增加净蛋白合成代谢。
当前文献表明,低热量、高蛋白肠内或肠外营养有望成为重症肥胖患者代谢支持的标准做法。实现净蛋白合成代谢和避免过度喂养并发症是主要目标,脂肪减重是令人欢迎的次要益处。