大脑磁共振成像的新进展。
New developments in magnetic resonance imaging of the brain.
作者信息
Koretsky Alan P
机构信息
Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20812, USA.
出版信息
NeuroRx. 2004 Jan;1(1):155-64. doi: 10.1602/neurorx.1.1.155.
Magnetic resonance imaging (MRI) continues to have a large impact on the diagnosis and management of a number of diseases, especially diseases associated with brain injury. The strengths of MRI are the unique contrast that can be obtained, and the fact that it is not harmful and that it can be readily applied to human and animal models. The past decade has seen development of functional MRI techniques that measure aspects of hemodynamics and water diffusion that are playing an important role. Indeed, these techniques are having a major impact on management of brain injury. The development of MRI continues at a rapid pace and a renewed push to increased spatial and temporal resolution will extend the applicability of anatomical and functional MRI. Increased interest in molecular imaging using MRI is increasing the number of processes that can be imaged in the brain. This work reviews some new developments that are being made in anatomical, functional, and molecular MRI of the brain, with comments about usefulness for work in the area of neuroprotection.
磁共振成像（MRI）在多种疾病的诊断和管理中持续发挥着重大作用，尤其是与脑损伤相关的疾病。MRI的优势在于能够获得独特的对比度，且无害，可轻松应用于人类和动物模型。在过去十年中，功能性MRI技术得到了发展，这些技术可测量血流动力学和水扩散的相关方面，发挥着重要作用。事实上，这些技术对脑损伤的管理产生了重大影响。MRI的发展仍在快速推进，提高空间和时间分辨率的新努力将扩展解剖学和功能性MRI的适用性。对使用MRI进行分子成像的兴趣日益浓厚，这增加了大脑中可成像的过程数量。本文综述了脑解剖学、功能性和分子MRI方面的一些新进展，并对其在神经保护领域工作的实用性进行了评论。
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