Brooks David J
Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, United Kingdom.
NeuroRx. 2004 Oct;1(4):482-91. doi: 10.1602/neurorx.1.4.482.
In this article, the role of functional imaging for providing objective evidence that grafts of fetal tissue can survive and form connections in Parkinson's and Huntington's disease patients is reviewed. The dissociation between dopamine storage capacity, clinical improvement, and normalization of brain metabolism in PD is discussed, and possible mechanisms underlying the phenomenon of dyskinesias off medication are presented. It is concluded the positron emission tomography and single photon emission computed tomography can provide valuable ancillary information alongside clinical observations but are not currently appropriate modalities for use as surrogate endpoints.
本文回顾了功能成像在为胎儿组织移植能够在帕金森病和亨廷顿病患者体内存活并形成连接提供客观证据方面的作用。讨论了帕金森病中多巴胺储存能力、临床改善和脑代谢正常化之间的分离现象，并提出了停药后运动障碍现象的潜在机制。得出的结论是，正电子发射断层扫描和单光子发射计算机断层扫描可在临床观察的同时提供有价值的辅助信息，但目前并非用作替代终点的合适方式。
