Kawamoto K, Uozumi T, Sakoda K, Mukada K, Kurisu K, Yano T
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Cancer. 1992 Jun 1;69(11):2688-96. doi: 10.1002/1097-0142(19920601)69:11<2688::aid-cncr2820691111>3.0.co;2-4.
The effects of bromocriptine (BC), a somatostatin analog (SMS), and heat on the secretion of growth hormone (GH) and prolactin (PRL), and on the morphologic features of human GH-secreting pituitary adenoma were studied in vitro. The treatment with BC, SMS, or heat (41.5 degrees C and 42.5 degrees C) markedly suppressed the secretion of GH and PRL from the adenoma cells and reduced the number of cells immunoreactive with GH or PRL. The combined treatment with BC and heat induced a marked reduction in the number of GH and PRL cells consistent with the effect on the secretion of GH and PRL. These results suggest that BC, SMS, and heat treatments produced the cytotoxic effects on pituitary adenoma cells, and that the simultaneous treatment of BC and heat enhanced this effect.
在体外研究了溴隐亭（BC）、生长抑素类似物（SMS）和热对生长激素（GH）和催乳素（PRL）分泌以及人分泌GH的垂体腺瘤形态学特征的影响。用BC、SMS或热（41.5℃和42.5℃）处理可显著抑制腺瘤细胞中GH和PRL的分泌，并减少与GH或PRL免疫反应的细胞数量。BC与热联合处理导致GH和PRL细胞数量显著减少，这与对GH和PRL分泌的影响一致。这些结果表明，BC、SMS和热处理对垂体腺瘤细胞产生了细胞毒性作用，并且BC与热同时处理增强了这种作用。
