Peer Michael, Csaszar Edina, Vorlaufer Elisabeth, Kopp Stephan, Chiba Peter
Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria.
Mini Rev Med Chem. 2005 Feb;5(2):165-72. doi: 10.2174/1389557053402738.
The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.
