Lankveld Daniëlle P K, Bull Sarah, Van Dijk Paul, Fink-Gremmels Johanna, Hellebrekers Ludo J
Section Anaesthesiology and Intensive Care, Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM, Utrecht, The Netherlands.
Vet Res. 2005 Mar-Apr;36(2):257-62. doi: 10.1051/vetres:2004061.
Ketamine is widely used in equine anaesthesia. Beside its anaesthetic and analgesic properties, ketamine possesses a cytokine-modulating activity. However, to date, no data are available regarding the inhibitory effect of ketamine on the cytokine response in horses. In horses, cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) play a pivotal role in the pathogenesis of equine endotoxaemia following gastrointestinal disorders. Hence, the objective of this study was to assess the influence of ketamine on LPS-induced TNF-alpha and IL-6 formation in an equine macrophage cell line (eCAS cells). The results demonstrate a cytokine-modulating activity of ketamine in an equine cell line, suggesting a beneficial role for ketamine in the treatment of equine endotoxaemia.
氯胺酮在马的麻醉中广泛应用。除了具有麻醉和镇痛特性外，氯胺酮还具有细胞因子调节活性。然而，迄今为止，尚无关于氯胺酮对马细胞因子反应抑制作用的数据。在马中，细胞因子如肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）在胃肠道疾病后马内毒素血症的发病机制中起关键作用。因此，本研究的目的是评估氯胺酮对马巨噬细胞系（eCAS细胞）中脂多糖（LPS）诱导的TNF-α和IL-6形成的影响。结果表明氯胺酮在马细胞系中具有细胞因子调节活性，提示氯胺酮在马内毒素血症治疗中具有有益作用。
