Markaki Sophia, Protopapas Athanasios, Milingos Spyros, Lazaris Dimitrios, Antsaklis Aris, Michalas Stylianos
Department of Histopathology, "Alexandra" Hospital, Athens, Greece.
Gynecol Oncol. 2005 Mar;96(3):860-4. doi: 10.1016/j.ygyno.2004.11.014.
Primary peritoneal mesothelioma is regarded as a fatal disease that presents with progressive ascites at a relatively late stage of its natural history. Differential diagnosis between this rare tumor and both serous papillary carcinoma of the peritoneum and ovary can be problematic.
A 54-year-old woman presented to our institution with a 4-month history of dull epigastric pain and increased abdominal girth. Exploratory laparotomy revealed the presence of extensive intraperitoneal dissemination of a malignant neoplasm without a recognizable primary site. Suboptimal cytoreduction was carried out, and histological diagnosis was that of a malignant epithelioid mesothelioma. This was confirmed with a panel of immunohistochemical markers. The patient despite having a complete response after adjuvant chemotherapy died 18 months after primary surgery.
No single immunohistochemical stain is pathognomonic of peritoneal primary malignant mesothelioma (PMM), and the results of a panel of antibodies should be interpreted to set the diagnosis.
原发性腹膜间皮瘤被视为一种致命疾病，在其自然病程的相对晚期会出现进行性腹水。这种罕见肿瘤与腹膜浆液性乳头状癌及卵巢浆液性乳头状癌之间的鉴别诊断可能存在问题。
一名54岁女性因上腹部隐痛4个月且腹围增大就诊于我院。剖腹探查发现腹腔内广泛播散的恶性肿瘤，未发现明确的原发部位。进行了减瘤手术，组织学诊断为恶性上皮样间皮瘤。通过一组免疫组化标志物得以证实。该患者尽管辅助化疗后获得完全缓解，但在初次手术后18个月死亡。
没有单一的免疫组化染色对腹膜原发性恶性间皮瘤（PMM）具有诊断特异性，应综合一组抗体的结果来做出诊断。
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