Salinas Patricia C, Price Stephen R
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Curr Opin Neurobiol. 2005 Feb;15(1):73-80. doi: 10.1016/j.conb.2005.01.001.
Cadherin-catenin complexes have been well established as key regulators of cell adhesion. Recent work has elucidated a pivotal role for these molecules in synaptic assembly, remodelling and plasticity. Far from being mere adhesive scaffolds, cadherins might directly regulate cell signalling to modulate synaptic connectivity.
钙黏蛋白-连环蛋白复合物已被确认为细胞黏附的关键调节因子。最近的研究阐明了这些分子在突触组装、重塑和可塑性方面的关键作用。钙黏蛋白远非仅仅是黏附支架,它们可能直接调节细胞信号传导以调节突触连接。