钙黏蛋白和连环蛋白在突触发育中的作用
Cadherins and catenins in synapse development.
作者信息
Salinas Patricia C, Price Stephen R
机构信息
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.
出版信息
Curr Opin Neurobiol. 2005 Feb;15(1):73-80. doi: 10.1016/j.conb.2005.01.001.
PMID:15721747
Abstract
Cadherin-catenin complexes have been well established as key regulators of cell adhesion. Recent work has elucidated a pivotal role for these molecules in synaptic assembly, remodelling and plasticity. Far from being mere adhesive scaffolds, cadherins might directly regulate cell signalling to modulate synaptic connectivity.
摘要
钙黏蛋白-连环蛋白复合物已被确认为细胞黏附的关键调节因子。最近的研究阐明了这些分子在突触组装、重塑和可塑性方面的关键作用。钙黏蛋白远非仅仅是黏附支架，它们可能直接调节细胞信号传导以调节突触连接。
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