Suzuki Kimihiro, Matsumoto Mitsuyo, Nakashima Masahiro, Takada Kunio, Nakanishi Takashi, Okada Makoto, Ohsuzu Fumitaka
Internal Medicine I, National Defense Medical College, Tokorozawa, Japan.
Pharmacology. 2005 May;74(2):100-5. doi: 10.1159/000084031. Epub 2005 Feb 18.
The aim of this study is to clarify the effects of cevimeline on various components in human saliva, such as immunoglobulin A (IgA), lysozyme, alpha-amylase and squamous cell carcinoma (SCC) antigen. Twelve female patients with Sjögren syndrome (SS) and 14 healthy women were enrolled. After the first saliva collection, one capsule (30 mg) of cevimeline was administered to each subject. Saliva was collected again after 90 min. The salivary flow rate and concentration of each component were measured. In both groups the salivary flow rate and amylase concentration were significantly increased by cevimeline. The lysozyme and IgA concentrations did not change significantly in both groups. The SCC antigen concentration did not change significantly in the SS group, but it decreased significantly in the control group. The secretion rates of amylase and IgA showed significant increases in both groups. The secretion rate of lysozyme significantly increased only in the control group, while the secretion rate of SCC significantly increased only in the SS group. Cevimeline augments not only the salivary flow rate but also the secretion rate of some digestive and/or defense factors from infections. It may be beneficial for SS patients to continue taking cevimeline to prevent oral infections, and other serious sequelae.
本研究的目的是阐明西维美林对人唾液中各种成分的影响，如免疫球蛋白A（IgA）、溶菌酶、α淀粉酶和鳞状细胞癌（SCC）抗原。招募了12名干燥综合征（SS）女性患者和14名健康女性。在首次采集唾液后，给每位受试者服用一粒西维美林胶囊（30毫克）。90分钟后再次采集唾液。测量唾液流速和各成分的浓度。在两组中，西维美林均显著提高了唾液流速和淀粉酶浓度。两组中溶菌酶和IgA浓度均无显著变化。SS组中SCC抗原浓度无显著变化，但在对照组中显著降低。淀粉酶和IgA的分泌率在两组中均显著增加。溶菌酶的分泌率仅在对照组中显著增加，而SCC的分泌率仅在SS组中显著增加。西维美林不仅增加唾液流速，还增加一些消化和/或抗感染防御因子的分泌率。SS患者继续服用西维美林以预防口腔感染和其他严重后遗症可能有益。
