Polypharmacy treatment approaches to the psychiatric and somatic comorbidities found in patients with chronic pain.

This review outlines the following: psychiatric and somatic comorbidities associated with chronic pain and their relationship to polypharmacy treatment, indications for polypharmacy in chronic pain, criteria for rational polypharmacy, basic principles of polypharmacy for pain-associated comorbidity, and, based on the above, psychopharmacologic polypharmacy treatment approaches to these chronic pain-associated comorbidities.