关卡信号传导：Mad2构象异构体与信号传播
Checkpoint signalling: Mad2 conformers and signal propagation.
作者信息
Hardwick Kevin G
机构信息
Wellcome Trust Centre for Cell Biology,University of Edinburgh, Edinburgh EH93JR, UK.
出版信息
Curr Biol. 2005 Feb 22;15(4):R122-4. doi: 10.1016/j.cub.2005.02.008.
PMID:15723780
Abstract
The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores.
摘要
纺锤体检查点蛋白Mad2倾向于形成多聚体，并至少采用两种结构构象。新的研究突出了Mad2与Mad2相互作用的重要性，并揭示了纺锤体检查点信号如何从着丝粒传播开来。
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