Cao Shuxia, Liu Hongmin, Xu Wen, Liao Xincheng, Zhao Yufen
Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China.
J Mass Spectrom. 2005 Apr;40(4):452-7. doi: 10.1002/jms.814.
Four indole derivatives synthesized from 2-keto glycosides were analyzed by electrospray ionization tandem mass spectrometry (ESI-MSn) with low-energy collision-induced dissociation to establish a general structural elucidation of indole derivatives. Their fragmentation pathways are proposed on the basis of the MSn studies and deuterium-labeled experiments. Indole derivatives undergo complicated gas-phase rearrangements in addition to simple bond cleavages. A rearrangement, which involves a contraction of the six-membered ring, was observed and a mechanism was proposed. The observations may have some potential applications in the interpretation of the mass spectra of indole derivatives.
对由2-酮糖苷合成的四种吲哚衍生物进行了电喷雾电离串联质谱（ESI-MSn）分析，并采用低能量碰撞诱导解离，以建立吲哚衍生物的通用结构解析方法。基于MSn研究和氘标记实验提出了它们的碎裂途径。吲哚衍生物除了简单的键断裂外，还会发生复杂的气相重排。观察到一种涉及六元环收缩的重排，并提出了一种机制。这些观察结果可能在吲哚衍生物质谱的解释中具有一些潜在应用。
