深板层角膜移植术后推测的基质移植排斥反应。
Presumed stromal graft rejection after deep anterior lamellar keratoplasty.
作者信息
Al-Torbak Abdullah, Malak Mohammad, Teichmann Klaus D, Wagoner Michael D
机构信息
Anterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
出版信息
Cornea. 2005 Mar;24(2):241-3. doi: 10.1097/01.ico.0000141230.95601.95.
PURPOSE
To demonstrate the development of presumed immune-mediated stromal rejection after deep anterior lamellar keratoplasty and its reversal after initiation of intensive topical corticosteroid therapy.
METHODS
Observational case report carried out with the approval of the hospital institutional review board.
RESULTS
Stromal edema and peripheral vascularization developed 16 months after deep anterior lamellar keratoplasty for keratoconus in a 13-year-old girl. After 2 weeks of intensive topical corticosteroids, complete reversal of stromal edema and regression of peripheral vascularization occurred, with full recovery of visual function.
CONCLUSION
The clinical appearance and response to therapy in this case support the diagnosis of immune-mediated stromal rejection. Ophthalmologists should be aware that sight-threatening stromal rejection may occur in lamellar corneal grafts.
目的
证明在深前板层角膜移植术后假定的免疫介导性基质排斥反应的发展情况以及在开始强化局部皮质类固醇治疗后其逆转情况。
方法
在医院机构审查委员会批准下进行观察性病例报告。
结果
一名13岁圆锥角膜女孩在接受深前板层角膜移植术后16个月出现基质水肿和周边血管化。在强化局部使用皮质类固醇2周后，基质水肿完全消退，周边血管化消退，视功能完全恢复。
结论
该病例的临床表现和对治疗的反应支持免疫介导性基质排斥反应的诊断。眼科医生应意识到板层角膜移植可能会发生威胁视力的基质排斥反应。
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