Hengstman G J D, van Brenk L, Vree Egberts W T M, van der Kooi E L, Borm G F, Padberg G W A M, van Venrooij W J, van Engelen B G M
Neuromuscular Centre Nijmegen, Dept. of Neurology, University Medical Centre Nijmegen, 9101, 6500 HB, Nijmegen, The Netherlands.
J Neurol. 2005 May;252(5):534-7. doi: 10.1007/s00415-005-0683-5. Epub 2005 Feb 23.
Myositis specific autoantibodies (MSAs) are proven to be specific for myositis compared with other inflammatory connective tissue diseases. Their specificity compared, however, with other neuromuscular disorders, which are included in the differential diagnosis of patients in whom the diagnosis myositis is under consideration, is unknown. We prospectively screened sera from 107 patients with various neuromuscular disorders for the most common MSAs and compared the results with the findings in a group of 97 myositis patients, published previously. Special attention was paid to patients with facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant muscle disease with marked inflammation in skeletal muscle tissue. Only one patient in the neuromuscular disorders group tested positive for an MSA, compared with 41 in the myositis group, resulting in a specificity of 99%. None of the FSHD patients tested positive. We conclude that the tested MSAs are highly specific for myositis and that they are not merely associated with muscle inflammation.
与其他炎症性结缔组织病相比，肌炎特异性自身抗体（MSA）已被证明对肌炎具有特异性。然而，与其他神经肌肉疾病相比，其特异性尚不清楚，而这些疾病包含在考虑诊断为肌炎的患者的鉴别诊断中。我们前瞻性地筛查了107例患有各种神经肌肉疾病的患者的血清，以检测最常见的MSA，并将结果与之前发表的一组97例肌炎患者的结果进行比较。特别关注了面肩肱型肌营养不良（FSHD）患者，这是一种常染色体显性遗传性肌肉疾病，骨骼肌组织有明显炎症。神经肌肉疾病组中只有1例患者MSA检测呈阳性，而肌炎组中有41例，特异性为99%。没有FSHD患者检测呈阳性。我们得出结论，所检测的MSA对肌炎具有高度特异性，且它们不仅仅与肌肉炎症相关。
