Marucci Gianluca, Betts Christine M, Liguori Luciano, Eusebi Vincenzo
Section of Pathology, Department of Oncology, University of Bologna, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy.
Virchows Arch. 2005 Mar;446(3):322-4. doi: 10.1007/s00428-004-1181-3. Epub 2005 Feb 22.
A case of basaloid carcinoma of the pancreas in a 26-year-old woman is reported. The tumour was constituted by solid nests of relatively uniform neoplastic cells with hyperchromatic nuclei and scant cytoplasm, showing distinct peripheral palisading. There were necrotic areas and deposition of hyaline material, suggesting a basement membrane-like substance. Small foci of clear-cut squamous differentiation were present. Tumour cells were positive for cytokeratin 14 and P63 and negative for neuroendocrine and acinic cell markers. Ultrastructurally, the tumour was constituted by polygonal cells with round nuclei containing clumped chromatin. Occasional tight junctions and keratin filaments were present. Basaloid carcinomas may arise in several sites of the body, the most frequent being the anus and oesophagus, and have poor clinical outcome. The present case appears to be, to the best of our knowledge, the first documented example in the literature of basaloid carcinoma of the pancreas.
报告了一例26岁女性胰腺基底样癌病例。肿瘤由相对均匀的肿瘤细胞实性巢组成，细胞核深染，细胞质稀少，显示出明显的周边栅栏状排列。存在坏死区域和透明物质沉积，提示为基底膜样物质。有明确的小灶性鳞状分化。肿瘤细胞细胞角蛋白14和P63阳性，神经内分泌和腺泡细胞标志物阴性。超微结构上，肿瘤由多边形细胞构成，圆形细胞核内有聚集的染色质。偶尔可见紧密连接和角蛋白丝。基底样癌可发生于身体的多个部位，最常见于肛门和食管，临床预后较差。据我们所知，本病例似乎是文献中首例有记录的胰腺基底样癌病例。
