Farrell Nicholas P
Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA.
Semin Oncol. 2004 Dec;31(6 Suppl 14):1-9. doi: 10.1053/j.seminoncol.2004.11.004.
Although platinum compounds have long been used in cancer chemotherapy, understanding the biochemistry and specific activity of these agents remains a focus of ongoing research, particularly with regard to next-generation platinum agents. This review will examine current knowledge and recent studies of the molecular mechanisms of platinum DNA damage and repair, including novel platinum DNA targets. Gene expression associated with platinum DNA damage will also be explored, as well as mechanisms of platinum-drug delivery, drug resistance, and future directions in the development of novel platinum agents.
尽管铂类化合物长期以来一直用于癌症化疗，但了解这些药物的生物化学和特定活性仍然是正在进行的研究重点，特别是对于下一代铂类药物而言。本综述将审视关于铂类DNA损伤与修复分子机制的现有知识和近期研究，包括新型铂类DNA靶点。还将探讨与铂类DNA损伤相关的基因表达，以及铂类药物递送、耐药性机制，以及新型铂类药物开发的未来方向。
