Urbani Simona, Boni Carolina, Amadei Barbara, Fisicaro Paola, Cerioni Simona, Valli Maria Antonietta, Missale Gabriele, Ferrari Carlo
Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, 43100 Parma, Italy.
Hepatology. 2005 Apr;41(4):826-31. doi: 10.1002/hep.20614.
To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.
为了表征与自限性和持续性乙型肝炎病毒（HBV）感染相关的急性期HBV特异性T细胞反应，我们将一名急性HBV/HCV合并感染且能够控制HCV但发展为慢性乙型肝炎的患者与自发清除急性HBV感染的患者进行了比较。急性期CD4反应在自限性感染中有效，但在HBV持续存在的合并感染患者中无法检测到。无论感染结果如何，CD8反应都是多特异性的，但与HBV持续存在相关的CD8库缺乏在自限性感染中可检测到的最主要特异性。总之，CD4辅助不足和CD8库缺陷可能在感染早期影响HBV持续存在中发挥作用。
