白细胞介素-6在恶性疟原虫疟疾期间维生素A缺乏中的作用以及维生素A补充的可能后果。
The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation.
作者信息
Tabone M D, Muanza K, Lyagoubi M, Jardel C, Pied S, Amedee-Manesme O, Grau G E, Mazier D
机构信息
INSERM U 313, Hôpital de la Salpétrière, Paris, France.
出版信息
Immunology. 1992 Mar;75(3):553-4.
Abstract
Kinetics of serum levels of interleukin-6 (IL-6) were studied in patients with acute Plasmodium falciparum malaria in relation to vitamin A and its binding proteins, retinol binding protein (RBP) and pre-albumin. It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. These data suggest that vitamin A supplementation alone might still be insufficient to restore a malaria-induced vitamin A deficiency.
摘要
研究了急性恶性疟原虫疟疾患者血清白细胞介素-6（IL-6）水平与维生素A及其结合蛋白、视黄醇结合蛋白（RBP）和前白蛋白的关系。发现IL-6水平在12小时内随疟原虫血症的上升和下降而变化，且与维生素A及其结合蛋白水平呈负相关。这些数据表明，仅补充维生素A可能仍不足以恢复疟疾引起的维生素A缺乏。
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本文引用的文献
1
Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency.患有轻度维生素A缺乏症的儿童患呼吸道疾病和腹泻的风险增加。
Am J Clin Nutr. 1984 Nov;40(5):1090-5. doi: 10.1093/ajcn/40.5.1090.
2
3
Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria.血清中肿瘤坏死因子α和白细胞介素-6水平升高作为重症恶性疟原虫疟疾的标志物。
Am J Med. 1989 Aug;87(2):139-43. doi: 10.1016/s0002-9343(89)80688-6.
4
5
Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia.实验性脑型疟中白细胞介素6的产生：抗细胞因子抗体的调节作用及其在高丙种球蛋白血症中的可能作用
J Exp Med. 1990 Nov 1;172(5):1505-8. doi: 10.1084/jem.172.5.1505.
6
Interleukin-6 and the acute phase response.白细胞介素-6与急性期反应。
Biochem J. 1990 Feb 1;265(3):621-36. doi: 10.1042/bj2650621.
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