Raza Adil, Khan Haris M, Malik Mohd Ashraf, Mahdi Abbas Ali, Shahid Mohd, Shujatullah Fatima
Department of Microbiology, J.N. Medical College and Hospital, AMU, India.
J Infect Dev Ctries. 2009 Dec 14;3(11):865-8.
Vitamin A (retinol)-deficiency and falciparum malaria are two major public health problems in developing countries. Falciparum malaria is associated with significant destruction of erythrocytes and can lead to severe anaemia.
The present study was designed to estimate the serum retinol concentration in 150 acute falciparum-malaria patients (aged two to five years) by High Performance Liquid Chromatography (HPLC). Serum retinol concentrations of 20 healthy (age and sex matched, population based) volunteers were included as controls.
The mean serum retinol concentration of healthy controls was 34.31 +/- 1.274 microg/dl and that of diseased cohort was 12.562 +/- 0.276 microg/dl. The mean parasitemia was 1239.2 +/- 33.609 per microL.
The diseased cohort demonstrated significant reduction in concentrations of retinol in comparison to healthy controls (p < 0.001) and there was an inverse relationship (coefficient of correlation r = -0.899) between parasitemia and serum retinol concentration.
维生素A（视黄醇）缺乏和恶性疟是发展中国家的两个主要公共卫生问题。恶性疟与红细胞的大量破坏有关，可导致严重贫血。
本研究旨在通过高效液相色谱法（HPLC）测定150例急性恶性疟患者（年龄在2至5岁之间）的血清视黄醇浓度。将20名健康（年龄和性别匹配、基于人群）志愿者的血清视黄醇浓度作为对照。
健康对照组的平均血清视黄醇浓度为34.31±1.274微克/分升，患病组为12.562±0.276微克/分升。平均寄生虫血症为每微升1239.2±33.609。
与健康对照组相比，患病组的视黄醇浓度显著降低（p<0.001），寄生虫血症与血清视黄醇浓度之间存在负相关关系（相关系数r=-0.899）。
