Ismail M M
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
Vet Res Commun. 2005 Jan;29(1):69-79. doi: 10.1023/b:verc.0000046738.52788.3c.
The pharmacokinetics of cefepime were studied following intravenous and intramuscular administration of 6.5 mg/kg in four female Friesian calves. Following single intravenous administration, the serum concentration-time curves of cefepime were best fitted using a two-compartment open model. The elimination half-life (t(1/2)beta) was 2.38+/-0.16 h, volume of distribution at steady state (Vdss) was 0.21 +/- 0.01 L/kg, and total body clearance (ClB) was 1.1 +/- 0.08 ml/min per kg. Following intramuscular administration, the drug was rapidly absorbed with an absorption half-life (t(1/2)ab) of 0.29+/-0.02 h; maximum serum concentration (Cmax) of 21.7 +/- 1.1 microg/ml was attained after (Tmax) 1.1 +/- 0.08 h; and the drug was eliminated with an elimination half-life (t(1/2)el) of 3.02 +/- 0.18 h. The systemic bioavailability (F) after intramuscular administration of cefepime in calves was 95.7% +/- 7.44%. The in vitro serum protein-binding tendency was 10.5-16.7%. Following administration by both routes, the drug was excreted in high concentrations in urine for 24 h post administration.
在4头雌性弗里斯兰犊牛中静脉注射和肌肉注射6.5mg/kg头孢吡肟后，对其药代动力学进行了研究。单次静脉注射后，头孢吡肟的血清浓度-时间曲线最适合用二室开放模型拟合。消除半衰期（t(1/2)β）为2.38±0.16小时，稳态分布容积（Vdss）为0.21±0.01L/kg，全身清除率（ClB）为每千克体重1.1±0.08ml/分钟。肌肉注射后，药物吸收迅速，吸收半衰期（t(1/2)ab）为0.29±0.02小时；给药后1.1±0.08小时达到最大血清浓度（Cmax）21.7±1.1μg/ml；药物消除半衰期（t(1/2)el）为3.02±0.18小时。犊牛肌肉注射头孢吡肟后的全身生物利用度（F）为95.7%±7.44%。体外血清蛋白结合率为10.5 - 16.7%。两种给药途径给药后，给药后24小时尿液中药物高浓度排泄。
