Kohli Punit, Martin Charles R
Department of Chemistry and Center for Research at Bio/Nano Interface, University of Florida, Gainesville, FL 32611, USA.
Curr Pharm Biotechnol. 2005 Feb;6(1):35-47. doi: 10.2174/1389201053167211.
Nanotechnology concerns the science of very small particles and deals with both the fundamental aspects of understanding the properties of such nanoparticles and with developing technological applications of nanoparticles. Biomedical and biotechnological applications of nanoparticles have been of special recent research and development interest, with potential applications that include use of nanoparticles as drug (or DNA) delivery vehicles, and as components in medical diagnostic kits, biosensors and membranes for bioseparations. Spherical nanoparticles are typically used for such applications, but this only reflects the fact that spheres are easier to make than nanoparticles having other shapes. Micro and nanotubes - structures that resemble tiny drinking straws - are alternatives and may offer advantages over spherical nanoparticles for some applications. This article discusses different approaches for making micro and nanotubes and reviews the current status of efforts to develop biomedical and biotechnological applications of these tubular structures.
纳米技术涉及极微小粒子的科学,既研究理解此类纳米粒子特性的基础方面,也致力于开发纳米粒子的技术应用。纳米粒子在生物医学和生物技术方面的应用是近期特别受研发关注的领域,其潜在应用包括将纳米粒子用作药物(或DNA)递送载体,以及用作医疗诊断试剂盒、生物传感器和生物分离膜的组件。球形纳米粒子通常用于此类应用,但这仅仅反映了球体比具有其他形状的纳米粒子更容易制造这一事实。微管和纳米管——类似于微小吸管的结构——是替代方案,并且在某些应用中可能比球形纳米粒子具有优势。本文讨论了制造微管和纳米管的不同方法,并综述了开发这些管状结构在生物医学和生物技术应用方面的研究现状。