Pravenec Michal, Kren Vladimír
Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic.
Exp Physiol. 2005 May;90(3):273-6. doi: 10.1113/expphysiol.2004.029322. Epub 2005 Feb 22.
Identification of the genetic determinants of common diseases is a major challenge for current biomedical research. Combining linkage analyses of essentially monogenic cis-regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.
识别常见疾病的遗传决定因素是当前生物医学研究面临的一项重大挑战。将本质上为单基因顺式调控表达表型的连锁分析与寡基因中间生理表型相结合，是在分子水平上识别数量性状基因座的一种有前景的方法。在本综述中，描述了对大鼠重组近交系中几个复杂水平研究的心血管表型的遗传分析。
