米卡芬净对环磷酰胺诱导的免疫抑制小鼠深部念珠菌病的疗效。
Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice.
作者信息
Ninomiya Mochiyoshi, Mikamo Hiroshige, Tanaka Kaori, Watanabe Kunitomo, Tamaya Teruhiko
机构信息
Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu, Japan.
出版信息
J Antimicrob Chemother. 2005 Apr;55(4):587-90. doi: 10.1093/jac/dki024. Epub 2005 Feb 22.
OBJECTIVES
We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model.
METHODS
We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously.
RESULTS AND CONCLUSIONS
Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.
目的
我们在环磷酰胺诱导的免疫抑制小鼠模型中研究了氟康唑和米卡芬净治疗深部念珠菌病的效果。
方法
我们使用了如前所述的由白色念珠菌引起的腹腔真菌脓肿实验模型。
结果与结论
即使在腹膜炎中，米卡芬净的疗效在剂量为氟康唑十分之一时仍与之相当。我们还评估了治疗结束后的短期（24小时）和长期（8天）治疗效果。尽管在治疗结束后24小时时氟康唑的治疗效果与米卡芬净相似，但在治疗结束后8天时米卡芬净的效果优于氟康唑。
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