• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ets-1是T-bet的功能性辅助因子，对Th1炎症反应至关重要。

Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.

作者信息

Grenningloh Roland, Kang Bok Yun, Ho I-Cheng

机构信息

Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

出版信息

J Exp Med. 2005 Feb 21;201(4):615-26. doi: 10.1084/jem.20041330.

DOI:10.1084/jem.20041330
PMID:15728239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2213045/
Abstract

To mount an effective type 1 immune response, type 1 T helper (Th1) cells must produce inflammatory cytokines and simultaneously suppress the expression of antiinflammatory cytokines. How these two processes are coordinately regulated at the molecular level is still unclear. In this paper, we show that the proto-oncogene E26 transformation-specific-1 (Ets-1) is necessary for T-bet to promote interferon-gamma production and that Ets-1 is essential for mounting effective Th1 inflammatory responses in vivo. In addition, Ets-1-deficient Th1 cells also produce a very high level of interleukin 10. Thus, Ets-1 plays a crucial and unique role in the reciprocal regulation of inflammatory and antiinflammatory Th responses.

摘要

为了启动有效的1型免疫反应，1型辅助性T（Th1）细胞必须产生炎性细胞因子，同时抑制抗炎性细胞因子的表达。这两个过程在分子水平上是如何协同调节的仍不清楚。在本文中，我们表明原癌基因E26转化特异性-1（Ets-1）是T-bet促进γ干扰素产生所必需的，并且Ets-1对于在体内启动有效的Th1炎性反应至关重要。此外，缺乏Ets-1的Th1细胞还会产生非常高水平的白细胞介素10。因此，Ets-1在炎性和抗炎性Th反应的相互调节中发挥着关键且独特的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/e3e67a238f49/20041330f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/4b08b6dbf8c7/20041330f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/1a0b9f09788d/20041330f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/767a6f4bbe19/20041330f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/4f86eece7b3c/20041330f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/5edd194465ee/20041330f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/f83b400a5baf/20041330f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/e3e67a238f49/20041330f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/4b08b6dbf8c7/20041330f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/1a0b9f09788d/20041330f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/767a6f4bbe19/20041330f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/4f86eece7b3c/20041330f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/5edd194465ee/20041330f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/f83b400a5baf/20041330f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58e/2213045/e3e67a238f49/20041330f7.jpg

相似文献

1
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.Ets-1是T-bet的功能性辅助因子，对Th1炎症反应至关重要。
J Exp Med. 2005 Feb 21;201(4):615-26. doi: 10.1084/jem.20041330.
2
Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells.Ets-1 与 HDAC1 的相互作用抑制 Th1 细胞中 IL-10 的表达。
J Immunol. 2012 Mar 1;188(5):2244-53. doi: 10.4049/jimmunol.1101614. Epub 2012 Jan 20.
3
Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.女性甾体激素利用信号转导子和转录激活子蛋白介导的信号通路来调节上皮细胞中T-bet的表达：一种人类生殖道局部免疫调节机制。
Mol Endocrinol. 2005 Aug;19(8):2047-59. doi: 10.1210/me.2004-0489. Epub 2005 Apr 28.
4
The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Ets-1转录因子是T细胞受体β基因座处完整的前T细胞受体功能和等位基因排斥所必需的。
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15712-7. doi: 10.1073/pnas.0405546101. Epub 2004 Oct 20.
5
Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients.c-Rel的易位缺陷与特应性皮炎患者T细胞中Th1细胞因子产生受损有关。
Exp Dermatol. 2005 Jan;14(1):17-25. doi: 10.1111/j.0906-6705.2005.00241.x.
6
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.T-bet通过对GATA-3功能的重要影响而非对IFNG基因的乙酰化和转录来调节Th1反应。
J Exp Med. 2006 Mar 20;203(3):755-66. doi: 10.1084/jem.20052165. Epub 2006 Mar 6.
7
Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene.Ets-1原癌基因失活诱导T细胞凋亡增加和B细胞终末分化。
Nature. 1995 Oct 19;377(6550):635-8. doi: 10.1038/377635a0.
8
IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.白细胞介素-2和长期T细胞活化诱导人T细胞中信号转导和转录激活因子5（STAT5）与ETS转录因子之间发生物理和功能相互作用。
Oncogene. 2000 Apr 20;19(17):2086-97. doi: 10.1038/sj.onc.1203542.
9
Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.T 细胞转录因子 T-bet 调控 Th1/Th17 平衡在禽分枝杆菌复合体病小鼠模型中的作用。
J Immunol. 2014 Feb 15;192(4):1707-17. doi: 10.4049/jimmunol.1302258. Epub 2014 Jan 20.
10
Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet.在缺乏Th1特异性转录因子T-bet的小鼠中，博来霉素诱导的皮肤纤维化增加。
Pathobiology. 2006;73(5):224-37. doi: 10.1159/000098208.

引用本文的文献

1
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.AP-1调节轴对天然Tγδ17细胞可塑性的限制
Nat Immunol. 2025 Jun 27. doi: 10.1038/s41590-025-02206-7.
2
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.AP-1调节轴对固有性Tγδ17细胞可塑性的限制
bioRxiv. 2024 Oct 18:2024.10.15.618522. doi: 10.1101/2024.10.15.618522.
3
Single-cell analysis of the survival mechanisms of fratricidal CAR-T targeting of T cell malignancies.靶向T细胞恶性肿瘤的自相残杀嵌合抗原受体T细胞（CAR-T）生存机制的单细胞分析

本文引用的文献

1
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.T 细胞转录因子 T-bet 调控自然杀伤细胞（NK 细胞）和 Vα14i 自然杀伤 T 细胞（NKT 细胞）的终末成熟及内稳态。
Immunity. 2004 Apr;20(4):477-94. doi: 10.1016/s1074-7613(04)00076-7.
2
T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii.c-Rel的T细胞内源性表达调节对弓形虫抵抗力至关重要的Th1细胞反应。
J Immunol. 2004 Mar 15;172(6):3704-11. doi: 10.4049/jimmunol.172.6.3704.
3
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells.
Mol Ther Nucleic Acids. 2024 May 20;35(2):102225. doi: 10.1016/j.omtn.2024.102225. eCollection 2024 Jun 11.
4
MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis.microRNA-125a-5p 通过靶向 ETS-1/STAT3 调节调节性 T 细胞对 Th1 和 Th17 的作用在银屑病中。
J Transl Med. 2023 Sep 29;21(1):678. doi: 10.1186/s12967-023-04427-6.
5
An update on the roles of transcription factor Ets1 in autoimmune diseases.转录因子 Ets1 在自身免疫性疾病中的作用研究进展。
WIREs Mech Dis. 2023 Nov-Dec;15(6):e1627. doi: 10.1002/wsbm.1627. Epub 2023 Aug 10.
6
T-BET and EOMES sustain mature human NK cell identity and antitumor function.T-BET 和 EOMES 维持成熟的人自然杀伤细胞特性和抗肿瘤功能。
J Clin Invest. 2023 Jul 3;133(13):e162530. doi: 10.1172/JCI162530.
7
Batf stabilizes Th17 cell development via impaired Stat5 recruitment of Ets1-Runx1 complexes.Batf 通过抑制 Stat5 募集 Ets1-Runx1 复合物来稳定 Th17 细胞的发育。
EMBO J. 2023 Apr 17;42(8):e109803. doi: 10.15252/embj.2021109803. Epub 2023 Mar 14.
8
The emerging role of Th1 cells in atherosclerosis and its implications for therapy.Th1 细胞在动脉粥样硬化中的新兴作用及其治疗意义。
Front Immunol. 2023 Jan 5;13:1079668. doi: 10.3389/fimmu.2022.1079668. eCollection 2022.
9
Case report: gene deletion associated with a low number of recent thymic emigrants in three patients with Jacobsen syndrome.病例报告：三名雅各布森综合征患者的基因缺失与近期胸腺迁出细胞数量减少有关。
Front Immunol. 2022 Oct 21;13:867206. doi: 10.3389/fimmu.2022.867206. eCollection 2022.
10
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.Th1 样细胞中致结肠炎表型的诱导依赖于白细胞介素-23 受体信号。
Immunity. 2022 Sep 13;55(9):1663-1679.e6. doi: 10.1016/j.immuni.2022.08.007. Epub 2022 Sep 6.
GATA-3缺陷会消除2型辅助性T细胞的发育和维持。
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1993-8. doi: 10.1073/pnas.0308697100. Epub 2004 Feb 9.
4
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression.未成熟Th细胞中Hlx的上调诱导干扰素-γ表达。
J Immunol. 2004 Jan 1;172(1):114-22. doi: 10.4049/jimmunol.172.1.114.
5
Stat5 activation plays a critical role in Th2 differentiation.Stat5激活在Th2分化中起关键作用。
Immunity. 2003 Nov;19(5):739-48. doi: 10.1016/s1074-7613(03)00292-9.
6
Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter.鉴定可赋予T-bet对近端γ-干扰素启动子反应性的协同单体短尾相关因子位点。
Int Immunol. 2003 Oct;15(10):1149-60. doi: 10.1093/intimm/dxg113.
7
Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo.体内诱导耐受性和调节性T1细胞分化的树突状细胞的特性分析。
Immunity. 2003 May;18(5):605-17. doi: 10.1016/s1074-7613(03)00113-4.
8
Molecular biology of the Ets family of transcription factors.转录因子Ets家族的分子生物学
Gene. 2003 Jan 16;303:11-34. doi: 10.1016/s0378-1119(02)01156-3.
9
Molecular mechanisms regulating Th1 immune responses.调节Th1免疫反应的分子机制。
Annu Rev Immunol. 2003;21:713-58. doi: 10.1146/annurev.immunol.21.120601.140942. Epub 2001 Dec 19.
10
A minimal IFN-gamma promoter confers Th1 selective expression.最小的干扰素-γ启动子赋予Th1选择性表达。
J Immunol. 2002 Oct 15;169(8):4205-12. doi: 10.4049/jimmunol.169.8.4205.