Cathcart H M, Huang R, Lanham I S, Corder E H, Poduslo S E
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA.
Neurology. 2005 Feb 22;64(4):755-7. doi: 10.1212/01.WNL.0000151980.42337.44.
Cystatin C, a protease inhibitor with widespread distribution, is upregulated in response to injury. Levels are elevated in the brains of patients with Alzheimer disease (AD). We compared frequencies for the CST 3 exon 1 polymorphism in patients with AD and controls. A proportional odds model indicated that the CST 3 A and APOE4 combination carried a high risk: a 14-fold elevation for men and 16-fold for women. These risks apply to risk at ages older than 64 years and to a shift in onset to ages younger than 65 years.
胱抑素C是一种分布广泛的蛋白酶抑制剂，在受到损伤时会上调。阿尔茨海默病（AD）患者大脑中的水平会升高。我们比较了AD患者和对照组中CST 3外显子1多态性的频率。比例优势模型表明，CST 3 A和APOE4组合具有高风险：男性风险升高14倍，女性升高16倍。这些风险适用于64岁以上人群的风险以及发病年龄向65岁以下人群的转变。
