1997年至2002年在加拿大获取的肺炎链球菌中大环内酯外排基因mef(A)和mef(E)的分子流行病学及流行情况
Molecular epidemiology and prevalence of macrolide efflux genes mef(A) and mef(E) in Streptococcus pneumoniae obtained in Canada from 1997 to 2002.
作者信息
Wierzbowski Aleksandra K, Swedlo Dean, Boyd Dave, Mulvey Michael, Nichol Kim A, Hoban Daryl J, Zhanel George G
机构信息
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Manitoba, Canada.
出版信息
Antimicrob Agents Chemother. 2005 Mar;49(3):1257-61. doi: 10.1128/AAC.49.3.1257-1261.2005.
Abstract
One hundred forty M phenotype Streptococcus pneumoniae isolates were evaluated by PCR-restriction fragment length polymorphism, serotyping, and pulsed-field gel electrophoresis. Molecular genotyping revealed that the predominant macrolide resistance mechanism in S. pneumoniae in Canada is mef(E) and resistance dissemination is due to both spread of the genetic element MEGA as well as clonal dissemination of penicillin- and/or macrolide-resistant strains.
摘要
通过聚合酶链反应-限制性片段长度多态性分析、血清分型和脉冲场凝胶电泳对140株M型肺炎链球菌分离株进行了评估。分子基因分型显示，加拿大肺炎链球菌中主要的大环内酯类耐药机制是mef(E)，耐药性传播是由于遗传元件MEGA的传播以及青霉素和/或大环内酯类耐药菌株的克隆传播。
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